1. Early Point Investment
After acquiring the starting trait, Crystalline Shadows, swing up the top path into Seeds of Doom, which is great dungeons and gearing up. Move left into Compounding Horror, which is arguably the strongest point on the entire tree for single target. Go through the minor utility of Long Dark Night of the Soul into your first Golden Trait, Soul Flame, which is exceptional for Mythic+ dungeons and the gearing process. It is not quite as dominant in raids, though it is still a great starting point regardless of your priorities.
1.1. Second Golden Trait!
Continue downwards along the Soul Flame path into Shadowy Incantations, which is a tasty overall damage increase. Pass through Hideous Corruption, which is great for both raids and dungeons (as it is spread by Seed of Corruption), and talent into your second Golden Trait. Wrath of Consumption is exceptional on fights with intermittent add spawns and is fantastic in dungeons. Unfortunately, it has little value on pure single target, but such encounters are in the minority.
1.2. Final Point Investment (i.e., wrapping things up).
Backtrack to Seeds of Doom and swing right into Inimitable Agony, a juicy increase, particularly on single target. Pass through the minor utility trait, Shadows of the Flesh, and invest in your final Golden Trait Harvester of Souls. This is an all around good trait in any situation and a nice way to finish your primary path.
Final point investment is more or less straightforward. Perdition is the easiest trait to acquire next and will result in the highest and most immediate damage increase. Sweet Souls is great if you are feeling fragile and need to beef up a bit, especially if you can convince your entire raid to switch back to Healthstones. Otherwise, ignore this trait for now and fill out Inherently Unstable for some additional crit chance on your Shard spender. Go through Drained to a Husk, which is very minor, and take Fatal Echoes. Although this trait seems attractive on the surface, it is an overall minor increase and only then on pure single target. There is also no good path to get here early, which is why Fatal Echoes is ignored until now. If you have not acquired Sweet Souls yet, finish your Ulthalesh, the Deadwind Harvester by allocating a point when available.
2. Relic Choice!
- Shadowy Incantations is good, particularly under the effects of Reap Souls.
- Inimitable Agony is great for single target, particularly in combination with Writhe in Agony.
- Inherently Unstable is another good single target relic, particularly when properly combined with Compounding Horror.
- Hideous Corruption and Seeds of Doom are both excellent relic slots for players invested mostly in Mythic+ progression.
- Drained to a Husk.
- Any defensive relic.